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In patients with creatinine clearance 10 ml min and 30 ml min, reduce the initial dose of zestril to half of the usual recommended dose i.
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In hemodynamic studies of zestril in patients with essential hypertension, blood pressure reduction was accompanied by a reduction in peripheral arterial resistance with little or no change in cardiac output and in heart rate.
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In these patients, zestril should be started under very close medical supervision and such patients should be followed closely for the first two weeks of treatment and whenever the dose of zestril and or diuretic is increased.
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adult patients administration of zestril to patients with hypertension results in a reduction of both supine and standing blood pressure to about the same extent with no compensatory tachycardia.